Low-molecular-weight adiponectin is more closely associated with episodes of asthma than high-molecular-weight adiponectin
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چکیده
منابع مشابه
Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?
INTRODUCTION The aim of this study was to analyse whether patients with occupational asthma (OA) caused by low molecular weight (LMW) agents differed from patients with OA caused by high molecular weight (HMW) with regard to risk factors, asthma presentation and severity, and response to various diagnostic tests. METHODS Seventy-eight patients with OA diagnosed by positive specific inhalation...
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Beneficial effects of peroxisome proliferator-activated receptor alpha (PPAR alpha) agonists have been reported in improving insulin sensitivity and raising serum total adiponectin. High molecular weight (HMW) adiponectin, which is secreted from adipocytes, and visfatin, which is also expressed in adipose tissue, is related to glucose metabolism. In view of the additive effects of PPAR alpha ag...
متن کاملType 2 diabetes in octogenarians is associated with decreased low molecular weight adiponectin.
BACKGROUND Adiponectin circulates in the blood in three different multimer isoforms, of which the high molecular weight form (HMW) is presumed to mediate insulin sensitivity. We examined whether adiponectin oligomer distribution is associated with aging and type 2 diabetes (T2D) in octogenarians without characteristic features of metabolic syndrome. METHODS The study included 154 octogenarian...
متن کاملSerum high molecular weight adiponectin is associated with mild renal dysfunction in Japanese adults.
AIMS Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults. METHODS We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 ± 14 (mean ± standard deviation; range, 20-89) years and 1,056 women aged 62 ± 12 (rang...
متن کاملPioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes.
Adiponectin is an adipocyte-derived serum protein that plays important roles in energy homeostasis, obesity, and insulin sensitivity. Using sucrose gradients and Western blotting of nondenaturing gels, we examined the adiponectin isoforms secreted from human adipose tissue, human and mouse adipocytes, and cell lines in response to pioglitazone added in vitro. The predominant form secreted from ...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2013
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.ej12-0277